Pancreatic secretory trypsin inhibitor (PSTI) isolated from pig intestine Influence on insulin and somatostatin release

FEBS Letters

Agerberth, Birgitta¹  Östenson, Claes-Göran²  Efendic, Suad²  Jörnvall, Hans³ 

[1] Department of Biochemistry II, Karolinska Institutet, S-104 01 Stockholm, Sweden;Department of Endocrinology, Karolinska Institutet, S-104 01 Stockholm, Sweden;Department of Chemistry I, Karolinska Institutet, S-104 01 Stockholm, Sweden

关键词: Pancreatic secretory trypsin inhibitor;    Pig intestine;    Trypsin inhibitor;    Perfused rat pancrease;   

DOI  :  10.1016/0014-5793(91)80399-N

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Upon investigation of pig intestinal peptides for effects on the relcuse of endocrine hormones from the isolated perfused rat pancreas, we reported earlier that glucose-stimulated insulin release was inhibited by PEC-60, a peptide with marked sequence similarity to PSTI (pancreatic secretory trypsin inhibitor). Continuing this study we found a polypeptide, which inhibited glucose-induced insulin release but enhanced glucose-induced somatostatin secretion. Determination of the amino acid sequence of this polypeptide revealed that it is identical to that of PSTI. Thus, PSTI modulates islet hormone release.

【 授权许可】

Unknown