Histidine decarboxylase gene expression in rat fundus is regulated by gastrin

FEBS Letters

Dimaline, R.¹  Sandvik, A.K.¹ 

[1] MRC Secretory Control Research Group, Department of Physiology, University of Liverpool, Liverpool, UK

关键词: Histidine decarboxylase;    Gastrin;    PCR;    mRNA;    Gene expression;    Rat fundus;   

DOI  :  10.1016/0014-5793(91)80348-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The conversion of histidine to histamine by histidine decarboxylase (HDC) is of central importance in the control of vertebrate acid secretion. We have used PCR-generated probes to study the regulation of HDC gene expression in rat fundic mucosa. When circulating gastrin levels were lowered by fasting or elevated by treatment with omeprazole, there were parallel changes in HDC mRNA abundance. However, when animals with elevated gastrin levels were concurrently treated with the gastrin/CCK-B receptor antagonist PD 134308, HDC mRNA levels were not increased. These data are consistent with the hypothesis that HDC gene expression is regulated by gastrin, over the physiological range of circulating hormone concentrations.

【 授权许可】

Unknown