Modeling by homology of RNA binding domain in A1 hnRNP protein

FEBS Letters

Ghetti, Andrea²  Cobianchi, Fabio¹  Morandi, Carlo²  Bolognesi, Martino³ 

[1] Istituto di Genetica Biochimica ed Evoluzionistica, CNR, Pavia, Italy;Istituto di Scienze Biologiche, Università di Verona, Strada Le Grazie 37134, Verona, Italy;Dipartimento di Genetica e Microbiologia, Sezione di Cristallografia, Università di Pavia, Pavia, Italy

关键词: RNA binding domain;    Acylphosphatase;    Modeling by homology;   

DOI  :  10.1016/0014-5793(90)80863-E

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Eukaryotic nuclear RNA binding proteins share a common sequence motif thought to be implicated in RNA binding. One of the two domains present in A1 hnRNP protein, has been modelled by homology in order to make a prediction of the main features of the RNA binding site. Acyl-phosphatase (EC 3.6.1.7) was selected as template for the modeling experiment. The predicted RNA binding site is a β-sheet containing the two RNP consensus sequences as well as lysines and arginines conserved among the family.

【 授权许可】

Unknown