FEBS Letters | |
The oral hypoglycemie agent, U‐56324, inhibits the activity of ATP‐sensitive potassium channels in cell‐free membrane patches from cultured mouse pancreatic B‐cells | |
Fatherazi, Sahba1  Cook, Daniel L.1  Hopkins, William F.1  | |
[1] Department of Physiology and Biophysics, and Medicine, University of Washington School of Medicine and Division of Metabolism (151), Seattle Veterans Administration Medical Center, 1660 South Columbian Way, Seattle, WA 98108, USA | |
关键词: Pancreatic B-cell; Potassium channel; Patch clamp; ATP; | |
DOI : 10.1016/0014-5793(90)80818-4 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
U-56324, a hypoglycemic agent derived from nicotinic acid, inhibited the activity of ATP-sensitive potassium channels in excised patches from mouse pancreatic B-cells. The effect of U-56324 on channel activity was reversible and concentration-dependent while it had no effect on single channel conductance. The positional isomer, U-59588, which has relatively little hypoglycemic activity, had no effect on channel properties. U-56324, at the same concentrations, had no effect on calcium-activated potassium channels. The basis for the potentially antidiabetic properties of U-56324 may therefore be due to direct and specific inhibition of ATP-sensitive potassium channels.
【 授权许可】
Unknown
【 预 览 】
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RO201912020294323ZK.pdf | 400KB | download |