The inhibition by pertussis and tetanus toxins of evoked catecholamine release from intact and permeabilized bovine adrenal chromaffin cells

FEBS Letters

Bansal, Mohinder K.¹  van Heyningen, Simon¹  Phillips, John H.¹ 

[1] Department of Biochemistry, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK

关键词: Tetanus toxin;    Pertussis toxin;    Adrenal cell;    Catecholamine;    Exocytosis;   

DOI  :  10.1016/0014-5793(90)80533-O

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Pertussis toxin stimulates both basal and nicotine-evoked catecholamine secretion from intact bovine adrenal chromaffin cells, as well as Ca²⁺-evoked release from permeabilized cells. Tetanus toxin inhibits all these effects; it reduces the secretion of intact cells treated with pertussis toxin to the basal level, and decreases by about 50% Ca²⁺-evoked release from permeabilized cells whether or not previously stimulated by pertussis toxin.

【 授权许可】

Unknown