期刊论文详细信息
FEBS Letters | |
The inhibition by pertussis and tetanus toxins of evoked catecholamine release from intact and permeabilized bovine adrenal chromaffin cells | |
Bansal, Mohinder K.1  van Heyningen, Simon1  Phillips, John H.1  | |
[1] Department of Biochemistry, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK | |
关键词: Tetanus toxin; Pertussis toxin; Adrenal cell; Catecholamine; Exocytosis; | |
DOI : 10.1016/0014-5793(90)80533-O | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Pertussis toxin stimulates both basal and nicotine-evoked catecholamine secretion from intact bovine adrenal chromaffin cells, as well as Ca2+-evoked release from permeabilized cells. Tetanus toxin inhibits all these effects; it reduces the secretion of intact cells treated with pertussis toxin to the basal level, and decreases by about 50% Ca2+-evoked release from permeabilized cells whether or not previously stimulated by pertussis toxin.
【 授权许可】
Unknown
【 预 览 】
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