Generation of human endothelin by cathepsin E

FEBS Letters

Capper, Stephen J.²  Kalinka, Siân²  Cook, Neil D.²  Meech, John²  Lees, Wendy E.¹  Kay, John¹ 

[1] Department of Biochemistry, University of Wales College of Cardiff, PO Box 903, Cardiff, CF11ST, UK;Development Group, Amersham International plc, Forest Farm, Whitchurch, Cardiff, CF4 7YT, Wales, UK

关键词: Cathepsin D;    Cathepsin E;    Big endothelin;    Endothelin generation;    big ET;    38 residue precursor of human endothelin-1;    ET;    21 residue endothelin-1;    CT;    17 residue C-terminal fragment of the big ET precursor;    TFA;    trifluoroacetic acid;   

DOI  :  10.1016/0014-5793(90)81060-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Highly-purified cathepsin D processed human big endothelin_1–38 into endothelin-like fragments but did not appear to generate endothelin_1–21 under the conditions employed. By contrast, human cathepsin E specifically cleaved human big endothelin into endothelin_1–21 and the C-terminal fragment under identical conditions but did not degrade either product further.

【 授权许可】

Unknown