期刊论文详细信息
FEBS Letters
Synthetic sialyl glycolipids (sialo‐cholesterol and sialo‐diglyceride) induce granulocytic differentiation of human myelogenous leukemia cell line HL‐60
Ogura, Haruo3  Saito, Masaki5  Tornita, Kenkichi1  Yuo, Akira5  Kitagawa, Seiichi5  Itoh, Masayoshi1  Nojiri, Hisao5  Ogino, Hidetoshi5  Nagai, Yoshitaka2  Ogawa, Tomoya4 
[1] Central Research Laboratory, MECT Co., Ltd, Tokyo 160, Japan;University of Tokyo, Tokyo 113, Japan;Kitasato University, Tokyo 108, Japan;Institute of Physical and Chemical Research, Wako 351-01, Japan;Division of Hemopoiesis, Institute of Hematology and Department of Medicine, Jichi Medical School, Tochigi 329-04, Japan
关键词: Sialo-cholesterol;    Sialo-diglyceride;    Granulocytic differentiation;    Myelogenous leukemia;    HL-60;    FMLP;    N-formyl-methionyl-leucyl-phenylalanine;    PMA;    phorbol myristate acetate;   
DOI  :  10.1016/0014-5793(90)80378-V
学科分类:生物化学/生物物理
来源: John Wiley & Sons Ltd.
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【 摘 要 】

When HL-60 cells were cultivated with synthetic sialyl glycolipids, sialo-cholesterol and sialo-diglyceride, the cells were found to be differentiated into mature granulocytes on morphological and functional criteria. The differentiation of cells was accompanied by inhibition of cell proliferation. The differentiation-inducing activity of sialo-cholesterol was greater than that of sialo-diglyceride on a molar basis, and the α-anomer of each compound was more potent than the β-anomer, suggesting that the stereospecific structure of the compounds is important for the differentiation-inducing activity.

【 授权许可】

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