Synthetic sialyl glycolipids (sialo‐cholesterol and sialo‐diglyceride) induce granulocytic differentiation of human myelogenous leukemia cell line HL‐60

FEBS Letters

Ogura, Haruo³  Saito, Masaki⁵  Tornita, Kenkichi¹  Yuo, Akira⁵  Kitagawa, Seiichi⁵  Itoh, Masayoshi¹  Nojiri, Hisao⁵  Ogino, Hidetoshi⁵  Nagai, Yoshitaka²  Ogawa, Tomoya⁴ 

[1] Central Research Laboratory, MECT Co., Ltd, Tokyo 160, Japan;University of Tokyo, Tokyo 113, Japan;Kitasato University, Tokyo 108, Japan;Institute of Physical and Chemical Research, Wako 351-01, Japan;Division of Hemopoiesis, Institute of Hematology and Department of Medicine, Jichi Medical School, Tochigi 329-04, Japan

关键词: Sialo-cholesterol;    Sialo-diglyceride;    Granulocytic differentiation;    Myelogenous leukemia;    HL-60;    FMLP;    N-formyl-methionyl-leucyl-phenylalanine;    PMA;    phorbol myristate acetate;   

DOI  :  10.1016/0014-5793(90)80378-V

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

When HL-60 cells were cultivated with synthetic sialyl glycolipids, sialo-cholesterol and sialo-diglyceride, the cells were found to be differentiated into mature granulocytes on morphological and functional criteria. The differentiation of cells was accompanied by inhibition of cell proliferation. The differentiation-inducing activity of sialo-cholesterol was greater than that of sialo-diglyceride on a molar basis, and the α-anomer of each compound was more potent than the β-anomer, suggesting that the stereospecific structure of the compounds is important for the differentiation-inducing activity.

【 授权许可】

Unknown