Effects of D600 on hypoxic suppresssion of K+ currents in isolated type I carotid body cells of the neonatal rat

FEBS Letters

Peers, C.¹ 

[1] University Laboratory of Physiology, Parks Rd, Oxford OX1 3PT, UK

关键词: Carotid body;    Hypoxia;    Patch-clamp;    K+ current;    Phenylalkylamine;    D600;    Verapamil;   

DOI  :  10.1016/0014-5793(90)80366-Q

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

K⁺ currents recorded from isolated type I carotid body cells were reversibly suppressed by hypoxia (pO₂ 25 Torr). Inhibition of Ca²⁺ influx using high Mg²⁺, low Ca²⁺ solutions abolished this effect, indicating hypoxia selectively inhibits the Ca²⁺-activa ted component of K⁺ currents. The Ca²⁺ channel blockers D600 and verapamil reversed the suppressive effects of hypoxia. These drugs also partially inhibited Ca²⁺-independent K⁺ currents, but this effect was relieved by hypoxia, causing apparent reversal of hypoxic suppression of the K⁺ currents seen under control conditions.

【 授权许可】

Unknown