Amino acid sequence elucidation of human acrosin‐trypsin inhibitor (HUSI‐II) reveals that Kazal‐type proteinase inhibitors are structurally related to β‐subunits of glycoprotein hormones

FEBS Letters

Eulitz, Manfred¹  Hehlein-Fink, Christa²  Fink, Edwin² 

[1] Institute for Clinical Molecular Biology, Gesellschaft für Strahlen- und Umweltforschung, Marchioninistrasse 25, D-8000 Munich 70, FRG;Department of Clinical Chemistry and Clinical Biochemistry, University of Munich, Nussbaumstrasse 20, D-8000 Munich 2, FRG

关键词: Kazal-type inhibitor;    Glycoprotein hormone β-subunit;    Acrosin-trypsin inhibitor (human seminal plasma);    Chorionic gonadotropin;    Luteinizing hormone;    PSTI;    pancreatic secretory trypsin inhibitor;    hCG;    human chorionie gonadotropin;    hLH;    human luteinizing hormone;    hFSH;    human follicle stimulating hormone;    hTSH;    human thyroidstimulating hormone;    suffix β;    β-subunit;   

DOI  :  10.1016/0014-5793(90)81273-Q

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The amino acid sequence of the acrosin-trypsin inhibitor HUSI-II from human seminal plasma is presented which unequivocally identifies HUSI-II as being of Kazal-type. In addition, the HUSI-II sequence shows a striking similarity to the middle part of glycoprotein hormone β-subunits thus revealing a hitherto unknown structural and evolutionary relationship between Kazal-type inhibitors and glycoprotein hormones.

【 授权许可】

Unknown