Rat lactate dehydrogenase A and B subunit concentrations are not regulated by mRNA abundance in liver and heart

FEBS Letters

Beebee, Trevor J.C.¹  Skidmore, Annette F.¹ 

[1] Department of Biochemistry, University of Sussex, Falmer, Brighton BN1 9QG, UK

关键词: Lactate dehydrogenase A;    Lactate hydrogenase B;    Developmental regulation;   

DOI  :  10.1016/0014-5793(90)81236-H

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

RNA was isolated from rat liver and heart tissues at various times up to 12 weeks after birth, and probed on slot blots with lactate dehydrogenase A and B cDNA probes. Although the relative abundances of LDH A in liver and LDH B in heart increased substantially in the 12 weeks after birth, mRNAs for both isoenzymes remained remarkably stable in both tissues over the same period. The implications of these observations for the regulation of constitutive gene expression are discussed.

【 授权许可】

Unknown