Prediction of arenavirus fusion peptides on the basis of computer analysis of envelope protein sequences

FEBS Letters

Glushakova, Svetlana E.²  Baratova, Ludmila A.¹  Lukashevich, Igor S.² 

[1] A.N. Belozersky Research Laboratory of Molecular Biology, Moscow State University, Lenin Hills, 119899 Moscow, U.S.S.R.;Department of Special Pathogens, Byelorussian Research Institute of Epidemiology and Microbiology, Nogina st. 3, 220050 MinskU.S.S.R.

关键词: Arenavirus;    Computer-assisted analysis of amino acid sequences;    Secondary structure prediction;    Fusion peptide;   

DOI  :  10.1016/0014-5793(90)81140-J

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Theoretical search and selection criteria for putative fusion peptides of enveloped viruses are proposed. Arena virus fusion peptides are predicted on the basis of computer-assisted analysis of amino acid sequences of arenavirus envelope proteins and elements of their secondary and tertiary structure. Accordingly, two regions of GP2 surface protein from 5 viruses of Arenaviridae family have been detected with properties typical of fusion peptides of other enveloped viruses. One region, named peptide IV, located at the N-terminus of the GP2 protein, is followed by the other region or peptide V, more likely candidate for the arenavirus fusion peptide.

【 授权许可】

Unknown