期刊论文详细信息
FEBS Letters | |
Mutual dependence of Na,K‐ATPase α‐ and β‐subunits for correct posttranslational processing and intracellular transport | |
Ackermann, U.1  Geering, K.1  | |
[1] Institut de Pharmacologie de l'Université, Bugnon 27, CH-1005 Lausanne, Switzerland | |
关键词: Na; K-ATPase; Protein biosynthesis; Protein oligomerization; Glycosylation processing; Protein degradation; Xenopus laevis; Oocyte; | |
DOI : 10.1016/0014-5793(90)81130-G | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
In this study, we have followed the fate of newly synthesized α- and β-subunits of Na,K-ATPase in Xenopus oocytes injected with α and/or β cRNA to examine whether assembly of the two subunits is needed for a correct folding and/or for intracellular transport of Na,K-ATPase. Our data indicate that (1) assembly of α- and β-subunits occurs at the level of the ER, (2) β-subunits are needed for the newly synthesized α-subunit to adopt a stable configuration and (3) α- and β-subunits mutually depend on each other to be transported out of the ER.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912020293762ZK.pdf | 475KB | download |