期刊论文详细信息
FEBS Letters | |
Porphyrin‐linked oligonucleotides | |
Abramova, T.V.1  Frolova, E.I.1  Zarytova, V.F.1  Vlassov, V.V.1  Ivanova, E.M.1  | |
[1] Institute of Bioorganic Chemistry, Siberian Division of the USSR Academy of Sciences, Prospekt Lavrentieva 8, Novosibirsk 630090, USSR | |
关键词: Antisense oligonucleotide; DNA affinity modification; (pN)16; oligonucleotide d(pTGACCCTCTTCCCATT); 5'Hem(pN)16 and 3'Hem(pN)16; oligonucleotide (pN)16 bearing hemin residue at the 5'- and at the 3'-end; respectively; 5'DHem(pN)16 and 3'DHem(pN)16; similar derivatives bearing the deuterohemin group; | |
DOI : 10.1016/0014-5793(90)81129-C | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Oligonucleotide derivatives bearing hemin and deuterohemin groups were synthesized. The derivatives efficiently react with the complementary nucleotide sequence in ssDNA forming covalent adducts and piperidine-labile sites. In the case of the deuterohemin derivative, some direct cleavage of the target DNA occurs.
【 授权许可】
Unknown
【 预 览 】
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