Porphyrin‐linked oligonucleotides

FEBS Letters

Abramova, T.V.¹  Frolova, E.I.¹  Zarytova, V.F.¹  Vlassov, V.V.¹  Ivanova, E.M.¹ 

[1] Institute of Bioorganic Chemistry, Siberian Division of the USSR Academy of Sciences, Prospekt Lavrentieva 8, Novosibirsk 630090, USSR

关键词: Antisense oligonucleotide;    DNA affinity modification;    (pN)16;    oligonucleotide d(pTGACCCTCTTCCCATT);    5'Hem(pN)16 and 3'Hem(pN)16;    oligonucleotide (pN)16 bearing hemin residue at the 5'- and at the 3'-end;    respectively;    5'DHem(pN)16 and 3'DHem(pN)16;    similar derivatives bearing the deuterohemin group;   

DOI  :  10.1016/0014-5793(90)81129-C

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Oligonucleotide derivatives bearing hemin and deuterohemin groups were synthesized. The derivatives efficiently react with the complementary nucleotide sequence in ssDNA forming covalent adducts and piperidine-labile sites. In the case of the deuterohemin derivative, some direct cleavage of the target DNA occurs.

【 授权许可】

Unknown