DNA demethylation in erythroleukaemia cells

FEBS Letters

Adams, R.L.P.¹  Hanley, A.¹  Rinaldi, A.¹ 

[1] Department of Biochemistry, University of Glasgow, Glasgow G12 8QQ, UK

关键词: DNA;    Methylcytosine;    MEL;    Friend erythroleukemia;    Demethylation;   

DOI  :  10.1016/0014-5793(90)81111-Z

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Despite a fall in the proportion of CGs methylated, evidence has not been obtained for significant demethylation of prelabelled DNA when mouse erythroleukaemia cells are induced to differentiate. There is, however, a delay in the methylation of the DNA that is synthesised in the early period of induction, leading to its undermethylation by 30–50% and this may be a contributory cause of the observed fall in CG methylation.

【 授权许可】

Unknown