The sequence of the hemoregulatory peptide is present in Giα proteins

FEBS Letters

Laerum, Ole Didrik¹  Kamp, Dietmar³  Tøn, Hege I.²  Frostad, Stein¹ 

[1] The Gade Institute, Department of Pathology, University of Bergen, Haukeland Hospital, N-5021 Bergen, Norway;Hafslund Nycomed, Bioreg Laboratories, Research Park, University of Oslo, Oslo, Norway;Laboratory of Biotechnology, University of Bergen, N-5021 Bergen, Norway

关键词: G-protein;    Hemopoiesis;    Hemoregulatory peptide;   

DOI  :  10.1016/0014-5793(90)81106-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The hemoregulatory peptide PyroGlu-Glu-Asp-Cys-Lys (HP5b), which inhibits myelopoietic colony formation in vitro, is shown to be a sequence motif which is also part of the effector domain of G_iα proteins. Out of 8 synthetic peptides with sequence variations of HP5b, those with the closest similarity to the G_iα sequence are biologically active. The inhibitory effect appears to be dependent on the blocked N-tenninus. It is postulated that these peptides may interfere with signal transduction mediated by G_α proteins.

【 授权许可】

Unknown