Receptor‐mediated calcium entry

FEBS Letters

Rink, Timothy J.¹ 

[1] Physiological Laboratory, Downing Street, Cambridge, CB2 3EG, UK

关键词: Ca2+;    Platelet;    Mn2+;    Fura-2;    Endothelium;    Patch-clamp;   

DOI  :  10.1016/0014-5793(90)81290-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Occupation of membrane receptors can evoke calcium signals by causing depolarisation and activating voltage-operated calcium channels, by triggering internal release, or by stimulating calcium influx processes not gated by membrane potential, receptor-mediated calcium entry, RCME. This brief review considers different possible coupling mechanisms and the proposal that entry can occur from external medium to intracellular store, by-passing the cytosol, and regulated by the state of filling of the store. Recent studies using Mn²⁺ as a probe for RCME are outlined, as are some new electrophysiologic measurements with human platelets and investigations of a novel blocker of RMCE, SK&F 96365.

【 授权许可】

Unknown