Accumulation of ornithine decarboxylase mRNA accompanies activation of human and mouse monocytes/macrophages

FEBS Letters

Messina, Angelo¹  Berton, Giorgio²  Messina, Luigi¹  Malaguarnera, Lucia¹  Kaczmarek, Leszek¹  Spampinato, Giuseppina¹  Arcidiacono, Antonio¹ 

[1] Institutes of General Pathology, University of Catania, Italy;Institutes of General Pathology, University of Verona, Italy

关键词: Ornithine decarboxylase;    Macrophage activation;    Interferon-γ;    Lipopolysaccharide;   

DOI  :  10.1016/0014-5793(90)80965-L

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Accumulation of ornithine decarboxylase (ODC) mRNA was investigated in human monocytes and mouse peritoneal macrophages. Treatment of both populations of mononuclear phagocytes with bacterial lipopolysaccharide induced a marked and rapid increase in the accumulation of the ODC gene transcript. A similar phenomenon, albeit less pronounced, was also observed following treatment of human monocytes with human recombinant interferon-γ. These results suggest a role for ODC, and therefore polyamines, in the regulation of mononuclear phagocyte functions.

【 授权许可】

Unknown