Expression of human α1‐antitrypsin using a recombinant adenovirus vector

FEBS Letters

Courtney, M.¹  Perricaudet, M.²  Pavirani, A.¹  Gilardi, P.² 

[1] Transgene SA, 11 Rue de Molsheim, 67082 Strasbourg Cedex, France;Institut Gustave Roussv, 39 Rue Camille Desmoulins, 94800 Villejuif, France

关键词: Antiprotease;    Serine protease;    α1-Antitrypsin;    Gene targeting: Drug delivery;    in vivo;    Recombinant adenovirus;   

DOI  :  10.1016/0014-5793(90)80287-S

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In order to improve the in vivo delivery of human proteins destined for replacement therapy, a recombinant adenovirus containing the cDNA sequence encoding human α₁-antitrypsin has been constructed and shown to direct expression of the protein in the supernatant of human cell lines.

【 授权许可】

Unknown