期刊论文详细信息
FEBS Letters | |
Metal ion co‐ordination in the DNA binding domain of the yeast transcriptional activator GAL4 | |
Povey, Jane F.2  Diakun, Gregory P.1  Laue, Ernest D.2  Garner, C.David3  Wilson, Stephen P.3  | |
[1] MRC/SERC Biology Support Laboratory, Daresbury Laboratory, Daresbury, Warrington, WA4 4AD UK;Department of Biochemistry, Tennis Court Road, Cambridge, CB2 1QW, UK;Department of Chemistry, University of Manchester, M13 9PL, UK | |
关键词: GAL4; Structure; DNA binding; Extended X-ray fine structure; Zinc finger; Saccharomyces cerevisiae; | |
DOI : 10.1016/0014-5793(90)81525-S | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The structure of the DNA binding domain of the yeast transcriptional activator GAL4 was investigated by extended X-ray fine structure (e.x.a.f.s.). Two samples of GAL4 were studied, one containing cadmium as a structural probe (Cd(II)GAL4) and the other containing the ‘native’ zinc (Zn(Il)-GAL4). The results suggest that the structure of the DNA binding domain of GAL4 contains a two metal ion cluster distinguishing it from the ‘zinc finger’ proteins typified by the Xenopus laevis transcription factor TFIIIA.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201912020293512ZK.pdf | 462KB | download |