Expression of genes coding for pS2, c‐erbB2, estrogen receptor and the H23 breast tumor‐associated antigen

FEBS Letters

Hareuveni, Mara²  Zaretsky, Joseph Z.²  Keydar, Iafa²  Tsarfaty, Ilan²  Weiss, Mordechai¹  Wreschner, Daniel H.² 

[1] Department of Internal Medicine, Sheba Medical Center, Tel Hashomer, Israel;Department of Microbiology, Faculty of Life Sciences, Tel Aviv University. Ramat Aviv, Israel

关键词: Gene expression;    Breast tumor antigen H23;    Breast tumor antigen pS2;    Oncogene erbB2;    Estrogen receptor;    Breast cancer;   

DOI  :  10.1016/0014-5793(90)80880-R

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Expression of the gene coding for a new breast tumor-associated antigen, H23, was compared to expression of genes coding for pS2, c-erbB2 and estrogen receptor (ER). Comparison involved mRNA expression in normal and malignant breast tissues as well as in non-breast tumors. Results obtained by RNA dot blot and Northern hybridizations showed that expression of the H23 antigen coding gene is a discriminatory marker in human breast cancer. It is expressed in 92% of breast tumors whereas 69%, 62% and 56% of breast tumors demonstrate significant mRNA levels of c-erbB2, ER and pS2, respectively. Non-malignant or normal breast tissue expresses much lower levels of the H23 antigen mRNA. From the comparative analysis presented here it is concluded that the gene coding for H23 antigen furnishes a most useful marker for human breast cancer.

【 授权许可】

Unknown