Cobalamin inactivation induces formyltetrahydrofolate synthetase

FEBS Letters

Deacon, Rosemary¹  Perry, Janet¹  Chanarin, I.¹  Lumb, M.¹ 

[1] Section of Haematology, MRC Clinical Research Centre, Northwick Park Hospital, Harrow, UK

关键词: Cobalamin;    Formate metabolism;    Formyltetrahydrofolate synthetase;    Cbl;    cobalamin;    CHO-H4PteGlu;    formyltetrahydropteroylglutamate synthetase;    MTA;    5′-methylthioadenosine;    N2O;    nitrous oxide;   

DOI  :  10.1016/0014-5793(90)81399-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Loss of cobalamin function produces profound changes in the metabolism of formate. There is impaired synthesis of formyltetrahydropteroylglutamate synthetase (CHO-H₄,PteGlu), accumulation of endogenous formate and impaired utilization of [^14C]formate. There are contradictory reports on the effect of cobalamin inactivation on CHO-H₄PteGlu synthetase. This study confirms a significant increase in synthetase activity following cobalamin inactivation.

【 授权许可】

Unknown