Induction of normal ultrastructure by CGRP treatment in dysgenic myotubes

FEBS Letters

Romey, Georges³  Lazdunski, Michel³  Garcia, Luis¹  Changeux, Jean-Pierre²  Rieger, François¹  Pinçon-Raymond, Martine¹ 

[1] Groupe de Biologie et Pathologie neuromusculaires, U.153 INSERM, 17 rue du Fer-á-Moulin, 75006 Paris, France;Unité de Neurobiologie moléculaire et UA.041149 CNRS, Interactions moléculaires et cellulaires, Département des Biotechnologies, Institut Pasteur, 25 rue du Dr. Roux, 75724 Paris, France;Institut de Pharmacologie moléculaire et cellulaire, UPR.411 CNRS, 660 route des Lucioles, Sophia Antipolis 06560 Valbonne, France

关键词: Muscle;    Calcitonin gene-related peptide;    Excitation-contraction coupling;    Ca2+ channel;    Triad;    Muscular dysgenesis;   

DOI  :  10.1016/0014-5793(90)80725-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The calcitonin gene-related peptide (CGRP) restores an apparant normal ultrastructure in mdg/mdg muscle cells in vitro, including a normal triadic organization which is known to be essential for excitation-contraction (E-C) coupling. However, neither slow L-type Ca²⁺ channel activity nor E-C coupling, which are absent in mdg/mdg muscle, were re-established. These observations suggest a potential role of CGRP (and also ofcAMP as the intracellular messenger) in the morphological development of the muscle fiber.

【 授权许可】

Unknown