Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome P45 0IA1 gene

FEBS Letters

Imai, Kazue¹  Watanabe, Junko²  Shinoda, Nahomi²  Yoshii, Akira³  Kawajiri, Kaname²  Nakachi, Kei² 

[1] Departments of Epidemiology, Saitama Cancer Center Research Institute, Saitama 362, Japan;Departments of Biochemistry, Saitama Cancer Center Research Institute, Saitama 362, Japan;Saitama Cancer Center Hospital, Ina-machi, Kitaadachi-gun, Saitama 362, Japan

关键词: Cytochrome P450IA1 gene;    Restriction fragment length polymorphism;    Lung cancer;   

DOI  :  10.1016/0014-5793(90)80721-T

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A good correlation was observed between enhanced lung cancer risk and restriction fragment length polymorphisms (RFLPs) of the P450IA1 gene with the restriction enzyme MspI. Genotype frequencies of 0.49 for the predominant homozygote, 0.40 for the heterozygote, and 0.11 for the homozygous rare allele were observed in a healthy population. Among lung cancer patients, the frequency of homozygous rare allele of P450IA1 gene was found to be about 3-fold higher than that among healthy population, and this difference was statistically significant. This is the first report to identify the genetically high risk individuals to lung cancer at the gene level.

【 授权许可】

Unknown