Time‐dependent inhibition of porcine kidney trehalase by aminosugars

FEBS Letters

Salleh, Hamzah Mohd.¹  Honek, John F.¹ 

[1] Guelph Waterloo Centre for Graduate Work in Chemistry, University of Waterloo, Waterloo, Ont. N2L 3G1 Canada

关键词: Trehalase;    Amino sugar;    Enzyme inhibition;    (Porcine kidney);   

DOI  :  10.1016/0014-5793(90)80229-C

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The inhibitory effects of various nitrogen-containing sugars on porcine kidney trehalase were studied. Validamycin A, validoxylamine A and MDL 25637 were found to be potent, time-dependent inhibitors of the enzyme in vitro. The validoxylamine A-inhibited enzyme showed slow but reversible reactivation over time (t = 1.2 h). To our knowledge, this is the first report of time-dependent inhibition exhibited by either these particular amino-sugars or a trehalase.

【 授权许可】

Unknown