The organisation of the mouse chromogranin B (secretogranin I) gene

FEBS Letters

Gerdes, Hans-Hermann¹  Rüther, Ulrich²  Phillips, Elizabeth¹  Pohl, Thomas M.²  Huttner, Wieland B.¹  Song, Kyuyong¹ 

[1] Cell Biology Programmes, European Molecular Biology Laboratory, Postfach 10.2209, D-6900 Heidelberg, FRG;Differentiation, European Molecular Biology Laboratory, Postfach 10.2209, D-6900 Heidelberg, FRG

关键词: Chromogranin;    Secretogranin;    Secretory granule;    Gene structure;    Promoter;    Transcription factor;    Cgs/Sgs;    chromogranins/secretogranins;    CgA;    chromogranin A;    CgB;    chromogranin B;    Sgll;    secretogranin II;    CRE;    cAMP-responsive element;   

DOI  :  10.1016/0014-5793(90)80194-N

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A cosmid clone containing the gene for mouse chromogranin B (secretogranin I), a secretory protein found in secretory granules of most endocrine cells and neurons, was isolated and sequenced. The chromogranin B protein was found to be encoded by 5 exons which correspond to the cleaved signal peptide, the short N-terminal sequence preceding the disulfide-bonded loop structure, the disulfide-bonded loop structure itself, the large, variable region comprising ~90% of the protein, and the conserved C-terminal sequence. The promoter region of the chromogranin B gene is very GC-rich and contains a CATAA motif, a cAMP-responsive element and an Spl binding site.

【 授权许可】

Unknown