Mannose‐6‐phosphate stimulates proliferation of neuronal precursor cells

FEBS Letters

Nielsen, Finn C.¹  Gammeltoft, Steen¹ 

[1] Department of Clinical Chemistry, Bispebjerg Hospital, DK-2400 Copenhagen NV, Denmark

关键词: Insulin-like growth factor;    Mannose-6-phosphate;    Receptor;    Mitogenesis;    Neuronal precursor cell;   

DOI  :  10.1016/0014-5793(90)80174-H

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The mitogenic signal function of mannose-6-phosphate (Man-6-P)/insulin-like growth factor II (IGF-II) receptors was studied in neuronal precursor cells from developing rat brain (E15). About 30% of the cellular Man-6-P/IGF-II receptors were present on the cell surface. Man-6-P and IGF-II stimulated DNA synthesis twofold and their effects were additive. Antibody 3637 to the Man-6-P/IGF-II receptor blocked the response to Man-6-P but not that to IGF-II. Other phosphorylated hexoses were also active. Fructose-1-phosphate was equally potent with Man-6-P, whereas glucose-6-phosphate was 5 times less potent. We conclude that Man-6-P-containing proteins and IGF-II act as mitogens in developing brain by interaction with the Man-6-P/IGF-II receptor and the IGF-I receptor, respectively.

【 授权许可】

Unknown