Effects of benzyl alcohol on transferrin and low density lipoprotein receptor mediated endocytosis in leukemic guinea pig B lymphocytes

FEBS Letters

Vidal, M.¹  Sainte-Marie, J.¹  Bienvenüe, A.¹  Vignes, M.¹  Philippot, J.R.¹ 

[1] URA-CNRS 530, Interactions Membranaires, Dept. Biologie Santé USTL, 34095 Montpellier, France

关键词: Receptor endocytosis;    Inhibition;    Benzyl alcohol;    L2C cell;   

DOI  :  10.1016/0014-5793(90)80141-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We demonstrated that benzyl alcohol, a neutral local anesthetic drug, inhibits the uptake and degradation of lowdensity lipoprotein and endocytosis of transferrin receptors of guinea pig leukemic B lymphocytes (L₂C). This inhibition is very rapid, concentration dependant and reversible by simple washing. Membrane fluidity of the living cells is also modified.

【 授权许可】

Unknown