Ligustrazine selectively blocks ATP‐sensitive K+ channels in mouse pancreatic β cells

FEBS Letters

Peers, C.¹  Nye, P.C.G.¹  Smith, P.A.¹ 

[1] University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, England

关键词: Ligustrazine;    ATP-sensitive potassium channel;    Potassium current;    Pancreatic β cell;   

DOI  :  10.1016/0014-5793(90)80622-P

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Ligustrazine potently inhibits hypoxic pulmonary vasoconstriction. This effect can be mimicked by the sulphonylurea tolbutamide, a blocker of ATP-sensitive K⁺ channels. Here we demonstrate that ligustrazine is a specific blocker of ATP-sensitive K⁺ channels in mouse pancreatic β cells. This suggests that ligustrazine may act in the pulmonary circulation by blocking ATP-sensitive K⁺ channels.

【 授权许可】

Unknown