Is the pseudo‐dyad in retroviral proteinase monomers structural or evolutionary?

FEBS Letters

Rao, J.K.Mohana¹  Wlodawer, Alexander¹ 

[1] Crystallography Laboratory, NCI-FCRF, BRI-Basic Research Program, PO Box B, Frederick, MD 21701, USA

关键词: Retroviral proteinase;    Rous sarcoma virus;    Human immunodeficiency virus-1;    Structural alignment;    Pseudo-dyad;   

DOI  :  10.1016/0014-5793(90)80103-P

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A pseudo-dyad was found to exist in the monomers of the crystal structures of the proteinases from Rous sarcoma virus and the human immunodeficiency virus. This dyad, also discovered earlier in pepsin-like aspartic proteinases and considered to be of probable evolutionary origin, has been shown to arise as a result of the topology and the folding of the proteinase monomers and may not therefore have much evolutionary significance.

【 授权许可】

Unknown