Liposome‐associated retinoic acid

FEBS Letters

Menegatti, Enea³  Nastruzzi, Claudio¹  Gambari, Roberto²  Walde, Peter¹ 

[1] Institut fur Polymere, ETH-Zentrum, CH-8092 Zurich, Switzerland;Biochemistry Institute, Ferrara University, 1-44100 Ferrara, Italy;Department of Pharmaceutical Sciences, Ferrara University, 1-44100 Ferrara, Italy

关键词: Retinoic acid;    Liposome;    Vesicle;    Tumor cell growth;    RA;    retinoic acid;    MLV-REV;    reverse phase evaporated multilamellar vesicles;    RSBP;    retinol-specific binding protein;    CRABP;    cellular retinoic acid binding protein;    PC;    phosphatidylcholine;   

DOI  :  10.1016/0014-5793(90)80030-M

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The activity of liposome-associated retinoic acid was analyzed on in vitro cultured tumor cell lines and compared to the antiproliferative effects of free retinoic acid. It was found that liposome-associated retinoic acid is about 300 times more active than free retinoic acid in inhibiting in vitro cell growth of leukemic and melanoma cell lines. An increased activity of retinoic acid (10–20 times) was also obtained after premixing of this compound with empty liposomes, demonstrating that the retinoic acid efficiently interacts with liposomes which may facilitate solubility and cell uptake of retinoids.

【 授权许可】

Unknown