Potent selective inhibitors of protein kinase C

FEBS Letters

Westmacott, Donald¹  Davis, Peter D.¹  Sedgwick, Anthony D.¹  Wilkinson, Sandra E.¹  Hill, Christopher H.¹  Keech, Elizabeth¹  Nixon, John S.¹  Lawton, Geoffrey¹  Wadsworth, Julie¹ 

[1] Research Centre, Roche Products Ltd, Broadwater Road, Welwyn Garden City, Herts., England

关键词: Protein kinase C;    Selective inhibition;    Platelet;    T cell;    Interleukin 2;    PKC;    protein kinase C;    PKA;    c-AMP dependent protein kinase;    TPA;    12-O-tetradecanoylphorbol 13-acetate;    PDBu;    phorbol 12;    13-dibutyrate;    DMSO;    dimethyl sulphoxide;    IL2;    interleukin 2;    SDS/PAGE;    sodium dodecyl sulphate/polyacrylamide gel electrophoresis;   

DOI  :  10.1016/0014-5793(89)81494-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A series of potent, selective inhibitors of protein kinase C has been derived from the structural lead provided by the microbial broth products, staurosporine and K252a. Our inhibitors block PCK in intact cells (platelets and T cells), and prevent the proliferation of mononuclear cells in response to interleukin 2 (IL2).

【 授权许可】

Unknown