Adrenal chromaffin granules and secretory granules from thyroid parafollicular cells have several common antigens

FEBS Letters

Gershon, Michael D.⁴  Hogue-Angeletti, Ruth¹  Cidon, Shulamit⁴  Weiler, Rosa²  Tamir, Hadassah³  Winkler, Hans² 

[1] Developmental Biology and Cancer, Albert Einstein College of Medicine, Bronx, NY 10461, USA;Department of Pharmacology, University of Innsbruck, Peter-Mayr-Straße la, A-6020 Innsbruck, Austria;Division of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA;Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA

关键词: Chromaffin granule;    Chromogranin A;    Chromogranin B;    Synaptin;    Synaptophysin;    Parafollicular cell thyroid;    Cytochrome b-561;   

DOI  :  10.1016/0014-5793(89)81595-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The presence of various antigens in two types of isolated endocrine vesicles (chromaffin granules and secretory vesicles of thyroid parafollicular cells) was investigated by immunoblotting. The twotypes of vesicles have three common secretory proteins: chromogranin A, chromogranin B and secretogranin II. Furthermore, six common membrane antigens were found: cytochrome b-561, carboxypeptidase H, glycoprotein II, glycoprotein III, synaptin/synaptophysin and SV 2. These results demonstrate that vesicles obtained from neural crest-derived endocrine cells not only share several common secretory peptides and proteins, but also have common properties as far as their membrane antigens are concerned.

【 授权许可】

Unknown