Presence of a basic amino acid residue at either position 66 or 122 is a condition for enzymic activity in the ribonuclease superfamily

FEBS Letters

Beintema, Jaap J.¹ 

[1] Biochemisch Laboratorium, Nijenborgh 16, 9747 AG Groningen, The Netherlands

关键词: Ribonuclease superfamily;    Amino acid position;    Active site conservation;    Ribonuclease activity;   

DOI  :  10.1016/0014-5793(89)80996-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Some members of the ribonuclease superfamily differ at more than 50% of the amino acid positions. Although the three-dimensional structures probably are very similar and the active-site residues have been conserved, other substrate-binding regions have changed considerably. Several proteins in the superfamily are active ribonucleases while others exhibit practically no enzymic activity. The presence of a basic residue at either position 66 or 122 appears to be a condition for ribonuclease activity.

【 授权许可】

Unknown