The distribution of a dopamine D2 receptor mRNA in rat brain

FEBS Letters

Weiner, David M.¹  Brann, Mark R.¹ 

[1] Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, Building 36 Room 3D-02, Bethesda, MD 20892, USA

关键词: Dopamine receptor;    Neurotransmitter receptor;    mRNA;   

DOI  :  10.1016/0014-5793(89)80960-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Based on the recently reported sequence of a dopamine D2 receptor cloned from rat brain, we prepared a series of cDNA probes to determine the distribution of mRNA encoding this receptor. Within the forebrain, D2 receptor mRNA is abundant in the caudate-putamen, accumbens nucleus and olfactory tubercle. Moderate to low levels of mRNA are observed in the medial habenular nucleus, diagonal band, lateral septal nucleus, claustrum, dorsal endopiriform nucleus, and entorhinal cortex. In the mesencephalon, D2 receptor mRNA is abundant within the substantia nigra, pars compacta, and the ventral tegmental area. Comparison of the distributions of the mRNA and ligand binding indicates that both presynaptic and postsynaptic D2 receptors of the nigrostriatal, mesolimbic and mesocortical pathways are derived from the same mRNA.

【 授权许可】

Unknown