Effect of persistent measles virus infection on protein kinase C activity and c‐fos protooncogene expression in neuroblastoma cells

FEBS Letters

Katorza, A.¹  Wolfson, M.¹  Segal, S.¹  Rager-Zisman, B.¹ 

[1]Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel

关键词: Protein kinase C;    Protooncogene;    c-fos;    (Murine neuroblastoma C1300);   

DOI  :  10.1016/0014-5793(89)80757-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effect of persistent measles virus infection on c-fos protooncogene and protein kinase C (PKC-I) gene expression in a murine neuroblastoma cell line was studied. Overexpression of c-fos protooncogene by infected NS20Y/MS cells was detected when compared with uninfected NS20Y cells. The level of PKC-I-specific mRNA was increased in infected NS20Y/MS cells. In addition, the level of total PKC activity in these cells was also enhanced. We conclude that persistent measles virus infection can alter both protooncogene expression and signal transduction in cells of neuronal origin.

【 授权许可】

Unknown