Fatty acid acylated antibodies against virus suppress its reproduction in cells

FEBS Letters

Bannikov, A.I.³  Severin, E.S.²  Kiselev, O.I.³  Kiselev, V.I.²  Alakhov, V.Yu.²  Ovcharenko, A.V.²  Melik-Hubarov, N.S.²  Sveshnikov, P.G.²  Kabanov, A.V.²  Levashov, A.V.¹ 

[1] Division of Chemical Enzymology, Department of Chemistry, Moscow State University, Leninskiye Gory, Moscow 117234, USSR;Research Center of Molecular Diagnostics, USSR Ministry of Health, Sympheropolsky blvd. 8, Moscow 113149, USSR;All- Union Institute of Gripp Research, USSR Ministry of Health, Professor Popov's str. 15/17, Leningrad 197022 USSR

关键词: Antibody;    Fatty acylation;    Virus suppression;    Influenza;    Hepes;    N-(2-hydroxyethyl)piperazinc-N′-2-ethanesulfonic acid sodium salt;    Aerosol OT;    bis-(2-ethylhexyl)-sulfosuccinate sodium salt;    PFU;    plaque forming units;    HAU;    hemagglutination unit;   

DOI  :  10.1016/0014-5793(89)80729-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A method for suppression of virus reproduction in cells using fatty acylated antiviral antibodies, which in contrast to non-modified antibodies are capable of intracellular penetration, has been suggested. The addition of stearoylated antiviral antibodies to influenza A/Chili virus-infected cells causes a 100-fold suppression of virus reproduction. Non-modified antibodies do not produce any effect on virus reproduction.

【 授权许可】

Unknown