S‐100a0 protein stimulates the basal (Mg2+‐activated) adenylate cyclase activity associated with skeletal muscle membranes

FEBS Letters

Aisa, M.C.²  Giambanco, I.²  Mariggiò, D.¹  Donato, R.²  Angelella, P.¹  Fanò, G.¹ 

[1] Institute of Cell Biology, Faculty of Sciences, University of Perugia, 06100 Perugia, Italy;Section of Anatomy, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06100 Perugia, Italy

关键词: Protein;    S-100a0;    Adenylate cyclase;    Enzyme regulation;    (Muscle cell);   

DOI  :  10.1016/0014-5793(89)80421-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

S-100a₀, protein, the αα isoform of the S-100 family, stimulates basal (Mg²⁺-activated) adenylate cyclase (AC) activity associated with the sarcolemma, longitudinal tubules and terminal cisternae of rat skeletal muscle cells. The stimulatory effect of S-100a₀ on AC activity is maximal around 5μM S-100a₀ and half-maximal around 0.2 μM S-100a₀. Also, the stimulatory effect is greatest on the AC activity associated with the terminal cisternae than on the other membrane fractions studied. These data are discussed in relation to the subcellular localization of S-100a₀ in muscle cells.

【 授权许可】

Unknown