Mitochondrial porin regulates the sensitivity of anion carriers to inhibitors

FEBS Letters

Rozhdestvenskaya, Zinaida E.¹  Pronevich, Ludmila A.¹  Mirzabekov, Tajib A.¹ 

[1] Institute of Biological Physics, USSR Academy of Sciences, Pushchino, Moscow Region 142292, USSR

关键词: Mitoplast;    Outer mitochondrial membrane;    Porin;    Uncoupler;    ATP/ADP antiporter;    Succinate carrier;    DNP;    2;    4-dinitrophenol;    CCCP;    m-chloro-phenylhydrazonecarbonyl cyanide;    FCCP;    p-trifluoromethoxy-phenylhydrazonecarbonyl cyanide;    CAT;    carboxyatractylate;   

DOI  :  10.1016/0014-5793(89)81363-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In mitoplasts, respiratory stimulation by ADP, palmitate, DNP and CCCP and sensitivity of respiration to carboxyatractylate are considerably less pronounced than in mitochondria. Addition of porin-containing preparations (purified outer membranes or solubilized mitochondrial porin) to mitoplasts results in partial restoration of the oxygen consumption and sensitivity to carboxyatractylate (CAT). The uncoupling effect of FCCP in mitoplasts is CAT-resistant and does not depend on added porin. It is suggested that mitochondrial porin may be a natural activator of ADP/ATP antiporter and succinate carrier in mitochondria.

【 授权许可】

Unknown