Bradykinin stimulates tumor necrosis factor and interleukin‐1 release from macrophages

FEBS Letters

Burch, Ronald M.¹  Tiffany, Carol W.¹ 

[1] Nova Pharmaceutical Corporation, 6200 Freeport Centre, Baltimore, MD 21224, USA

关键词: Bradykinin;    Cytokine;    Tumor necrosis factor;    Interleukin-1;    Macrophage;    Bradykinin antagonist;   

DOI  :  10.1016/0014-5793(89)81331-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Bradykinin and related kinins have been implicated in the initiation and maintenance of inflammation. Cytokines appear to be the primary mediators of many inflammatory diseases. The potential ability of bradykinin to stimulate release of tumor necrosis factor and interleukin-1 from macrophages was examined. Bradykinin stimulated release of both cytokines from P388-D1 and RAW264.7 murine macrophages. Studies with selective agonists and antagonists suggest that cytokine release is mediated by a B₁ kinin receptor.

【 授权许可】

Unknown