Studies on the mechanism of inhibition of nuclear triiodothyronine binding by fatty acids

FEBS Letters

Wiersinga, W.M.¹  van der Klis, F.R.M.¹  de Vijlder, J.J.M.¹ 

[1] Department of Experimental Endocrinology, University of Amsterdam, Amsterdam, The Netherlands

关键词: Unsaturated fatty acid;    Triiodothyronine;    Nuclear triiodothyronine receptor;    Albumin;    T3;    triiodothyronine;    OA;    oleic acid;    BSA;    bovine serum albumin;   

DOI  :  10.1016/0014-5793(89)80242-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Studies were designed to elucidate the mechanism by which unsaturated fatty acids inhibit the binding of triiodothyronine (T3) ro rat liver nuclei. The possibility of a direct interaction between oleic acid and T3 was excluded by dialysis experiments. Oleic acid inhibits nuclear T3 binding in a strictly competitive manner. The K _i value of oleic acid was approx. 10⁴ times greater than that of T3. The inhibitory effect of oleic acid could be reversed by bovine serum albumin.

【 授权许可】

Unknown