Evidence for the appearance of a reticulocyte population low in lipoxygenase mRNA during the recovery from a phenylhydrazine‐induced anemia in rabbits

FEBS Letters

Thiele, B.J.²  Oleinikov, A.V.¹  Höhne, M.²  Evdokimova, V.M.¹  Rapoport, S.M.²  Minich, W.B.¹ 

[1] Institute of Protein Research, Academy of Sciences of the USSR, Pushchino, Moscow Region, USSR;Institute of Biochemistry, Humboldt University Berlin, Hessische Strasse 3-4, DDR-1040 Berlin, GDR

关键词: Lipoxygenase;    mRNA;    Phenylhydrazine;    Anemia;    (Reticulocyte);   

DOI  :  10.1016/0014-5793(89)80205-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

It is shown that during recovery from a phenylhydrazine-induced anemia in rabbits a selective decrease in lipoxygenase mRNA takes place with a corresponding shut-off of the synthesis of the enzyme. It is suggested that a new population, ‘recovery’-reticulocytes, makes its appearance in the peripheral blood. Their cells are more mature than the stress macroreticulocytes. A cell-free system prepared from the recovery-reticulocytes exhibits low endogenous synthesis of non-globin polypeptides, even without nuclease treatment, but retains full capacity to be stimulated by exogenous mRNA.

【 授权许可】

Unknown