Species‐specific variation in signal peptide design Implications for protein secretion in foreign hosts

FEBS Letters

Abrahmsèn, Lars¹  von Heijne, Gunnar² 

[1] Department of Biochemistry, Royal Institute of Technology, S-100 44 Stockholm, Sweden;Department of Molecular Biology, Center for Biotechnology, Karolinska Institutet, Huddinge Hospital-K87, S-141 86 Huddinge Sweden

关键词: Protein secretion;    Signal peptide;    Leader peptide;   

DOI  :  10.1016/0014-5793(89)80579-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Secretory signal peptides from individual prokaryotic and eukaryotic species have been analyzed, and the lengths and amino acid compositions of the positively charged amino-terminal region, the central hydrophobic region, and the carboxy-terminal cleavage-region have been compared. We find distinct differences between species in all three regions. Implications for protein secretion in foreign hosts are discussed.

【 授权许可】

Unknown