期刊论文详细信息
FEBS Letters | |
The microheterogeneity of rat TBG | |
Nunez, Emmanuel A.1  Savu, Lia1  Vranckx, Roger1  | |
[1] U224, INSERM, Faculté de Médecine Xavier Bichat, Laboratoire de Biochimie, 16, rue Henri Huchard, 75018 Paris, France | |
关键词: Thyroxine-binding globulin; Microheterogeneity; Thyroid hormone-binding protein; (Rat); TBG; thyroxine-binding globulin; | |
DOI : 10.1016/0014-5793(89)80559-9 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Isoelectric focusing (IEF) of native sera from immature or adult rats and of purified or partially purified rat serum thyroid hormone-binding proteins, demonstrates that rat TBG is a microheterogeneous protein. Autoradiography and radioactivity scans of the IEF plates show that it consists of at least four main isoforms, with bands at pH 4.35, 4.45, 4.5 and 4.55. This pattern is remarkably similar to that reported for human TBG. This is the first demonstration of the polymorphism of this recently discovered major binding protein of the rat.
【 授权许可】
Unknown
【 预 览 】
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