期刊论文详细信息
FEBS Letters | |
Evidence for the monomeric nature of thymosins | |
Felix, A.M.4  Heimer, E.P.4  Hannappel, E.3  Yialouris, P.P.2  Haritos, A.A.2  Rosemeyer, M.A.1  | |
[1] Department of Biochemistry, University College London, Gower Street, London WC1E 6BT, England;Zoological Laboratory, Faculty of Sciences, University of Athens, GR 157 84 Athens, Greece;Institut für Biochemie, Medizinische Fakultät der Universität Erlangen, Nürnberg, Fahrstrasse 17, 8520 Erlangen, FRG;Peptide Research Department, Roche Research Center, Hoffmann-La Roche Inc., Nutley, NJ 07110, USA | |
关键词: Prothymosin α; Thymosin β4; Sedimentation equilibrium; Gel filtration; | |
DOI : 10.1016/0014-5793(89)80547-2 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
According to gel-filtration experiments, α- and β-thymosins appear to form oligomers, which are 4-5-fold larger than the corresponding polypeptides. However, on analysis by sedimentation equilibrium ultracentrifugation, prothymosin α and thymosin β4 showed relative molecular masses of 12 800 and 4600, which are close to the values calculated from their amino acid sequences, confirming their existence in solution as discrete monomeric entities.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912020291662ZK.pdf | 289KB | download |