Eicosapentaenoic acid and docosahexaenoic acid are antagonists at the thromboxane A2/prostaglandin H2 receptor in human platelets

FEBS Letters

Venton, Duane L.¹  Le Breton, Guy C.¹  Swann, Patrick G.¹ 

[1] Department of Pharmacology, College of Medicine University of Illinois at Chicago, Chicago, IL 60612, USA

关键词: Platelet;    Thromboxane receptor;    Fatty acid;   

DOI  :  10.1016/0014-5793(89)80137-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The present study investigated the mechanism by which eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) inhibit platelet activation induced by thromboxane A₂. DHA was found to be more potent than EPA in blocking platelet aggregation induced by the stable thromboxane A₂ mimetic, U46619. Furthermore, this inhibition by DHA or EPA was competitive. Binding studies using ³H-U46619 demonstrated that both EPA and DHA interact with the platelet thromboxane receptor. The potency of the inhibition of binding corresponded with that seen for the inhibition of aggregation. These results suggest that thromboxane receptor antagonism may be an important mechanism by which EPA and DHA modulate platelet reactivity in vivo.

【 授权许可】

Unknown