Glucose‐induced cAMP signaling in Saccharomyces cerevisiae is mediated by the CDC25 protein

FEBS Letters

Munder, Thomas¹  Küntzel, Hans¹ 

[1] Max-Planck-Institut für experimentelle Medizin, Abteilung Chemie, Hermann-Rein-Str. 3, D-3400 Göttingen, FRG

关键词: CDC25 protein;    cyclic AMP;    Glucose sensing;    Signal transduction;    Sporulation;    (Saccharomyces cerevisiae);   

DOI  :  10.1016/0014-5793(89)80498-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Functional mapping of the cell cycle START gene CDC25 has revealed two domains which are dispensable for viability (germination and growth in glucose media), but are essential for sporulation and differentially involved in glucose-induced cAMP signaling. The transient rise of cAMP is completely prevented by various deletions within the amino-terminal half (α domain) of the CDC25 gene product. In contrast, the deletion of the carboxy-terminal 38 residues (β2 domain) results in a rapid, but persisting, rise of cAMP. Our data suggest that the α domain of the CDC25 protein is involved in glucose signal transduction, whereas the β2 domain is required for downregulating the cAMP control chain.

【 授权许可】

Unknown