Endothelin stimulates c‐fos and c‐myc expression and proliferation of vascular smooth muscle cells

FEBS Letters

Yazaki, Yoshio¹  Kurihara, Hiroki¹  Sugiyama, Takao¹  Komuro, Issei¹  Takaku, Fumimaro¹ 

[1]The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113, Japan

关键词: Endothelin;    Ca2+;    c-myc gene;    c-fos gene;    Atherosclerosis;    (Vascular smooth muscle);    EDT;    endothelin;    VSMC;    vascular smooth muscle cell;    [Ca2+]i;    intracellular calcium;    EC;    endothelial cell;    PDGF;    platelet-derived growth factor;    EGF;    epidermal growth factor;    FCS;    fetal calf serum;    DMEM;    Dulbecco's modified Eagle's medium;    PBS;    phosphate-buffered saline;   

DOI  :  10.1016/0014-5793(88)80489-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Recently, a potent vasoconstrictor peptide, endothelin (EDT), was isolated from vascular endothelial cells. We examined its effect on rat vascular smooth muscle cells (VSMCs). EDT induced the elevation of intracellular calcium, which was dependent on extracellular calcium and inhibited by a calcium-channel antagonist in a competitive manner. EDT caused a rapid and transient increase in the c-fos and c-myc mRNA levels and stimulated the DNA synthesis of VSMCs in a dose-dependent manner. This effect of EDT on the proliferation of VSMCs might be related to the development of atherosclerosis.

【 授权许可】

Unknown