The ‘molten globule’ state is involved in the translocation of proteins across membranes?

FEBS Letters

Bychkova, Valentina E.¹  Pain, Roger H.²  Ptitsyn, Oleg B.¹ 

[1] Institute of Protein Research, Academy of Sciences of the USSR, 142292 Pushchino, Moscow Region, USSR;Department of Biochemistry, School of Biomedical and Biomolecular Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, England

关键词: Protein folding;    Molten globule state;    Protein translocation;    Membrane translation;    Deraturation;   

DOI  :  10.1016/0014-5793(88)80485-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Strong evidence exists that the translocation of proteins across a variety of membranes involves a non-native or denatured conformational states. On the other hand a compact state having secondary but not rigid tertiary structure and called the ‘molten globule’ state has been identified as being stable under mild denaturing conditions. A similar state has been shown to accumulate on the folding pathway of globular proteins. These states are compact though sufficiently expanded to include water, and they are internally mobile. It is proposed that these molten globule states may be suitable candidates for protein translocation across biological membranes.

【 授权许可】

Unknown