Amino acid sequence microheterogeneities of a type I cytokeratin of M r 51 000 from Xenopus laevis epidermis

FEBS Letters

Hoffmann, Werner¹  Königstorfer, Andreas¹  Sterrer, Sylvia¹ 

[1] Max-Planck-Institut für Psychiatrie, Abteilung Neurochemie, Martinsried, FRG and Institut für Molekularbiologie der Österreichischen Akademie der Wissenschaften, Salzburg, Austria

关键词: Cytokeratin;    Intermediate filament;    cDNA cloning;    (Xenopus;    Frog skin);   

DOI  :  10.1016/0014-5793(88)80196-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The complete cDNA-derived sequence of a type I cytokeratin (designated no. 3) from Xenopus laevis skin is described. The deduced protein has an M _r of 51 888 and consists of a glycine-rich head domain, a well-conserved α-helical region and a tail rich in hydroxyamino acid residues. Various cDNA clones encoding two different mRNAs were isolated that differed by short deletions/insertions and point mutations. These microheterogeneities are mainly located in a ‘hypervariable region’ at the C-terminal non-α-helical region.

【 授权许可】

Unknown