Globo‐A ‐ a new receptor specificity for attaching Escherichia coli

FEBS Letters

Edén, C.Svanborg²  Cedergren, B.¹  Baker, N.²  Larson, G.³  Senior, D.²  Falk, P.³  Lindstedt, R.² 

[1] The Blood Bank, University Hospital, University of Umeå, Umeå, Sweden;Departments of Clinical Immunology, University of Göteborg, Göteborg Sweden;Department of Clinical Chemistry, University of Göteborg, Göteborg Sweden

关键词: Bacterial attachment;    Glycolipid receptor;    Globoseries;    (E. coli);   

DOI  :  10.1016/0014-5793(88)80184-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Uropathogenic Escherichia coli strains designated as ONAP, based on their O negative A positive agglutination of human P₁ erythrocytes, were shown to prefer the globo-A glycolipid as a receptor structure. The dependence on both the A terminal and the globoseries chain was confirmed by agglutination of human AP₁, but not A or OP₁, erythrocytes and by binding to the globo-A glycolipid on TLC plates. Neither Galαl→Ga1β nor the A trisaccharide GalNAcαl→ 3(Fucαl→2)Galβ alone functioned as receptors. The bacteria thus appeared to recognize an epitope resulting from the combination of the terminal and internal structures.

【 授权许可】

Unknown